… derivatives and evodiamine, we hypothesized the bis-β-carboline derivatives might display
antitumor activity via both Top1 and Top2 inhibition. Therefore, the inhibitory activity of …

… In summary, a number of novel β-carboline derivatives described in this paper proved to be
potent antitumor agents. The N 2 -benzylated β-carbolinium bromides 56–60 were found to …

… Therefore, development of new anticancer drugs and more effective treatment strategies
for cancer are of utmost importance as traditionally prescribed chemotherapeutic agents have …

… Anticancer drugs have been categorized in consonance with their mechanism of action
as molecular targeting agents, antimetabolites, anti-tubulin and DNA-interactive …

… to find new β-carboline congeners that possess potential antitumor activity, … β-carboline
hybrids. These new hybrid molecules comprising two pharmacophoric groups (ie, a β-carboline …

… The potential of β-carbolines and the importance of the search for new antitumor agents led
… In previous works, we reported the synthesis and in vitro antitumor activities, against a panel …

… , and the majority of anticancer drugs currently used in clinical settings are derived from
natural product scaffolds such as paclitaxel and vinblastine. β-Carboline is made up of planar …

… for novel antitumor agents endowed with better antitumor … relationships (SARs) on the
antitumor efficacies in vitro and in … dimeric β-carboline derivatives as potent antitumor agents. …

… Among the synthesized series, compounds 3 and 7a are most prominent anticancer agent
… , the new classes of these betacarboline molecules are highly potential anticancer agents. …

… antitumor agents, we previously reported three series of potent cytotoxic compounds,
characterized by the presence of γ-carboline … : the planar γ-carboline acts as the hydrophobic ring …