… channel gene SCN5A cause Brugada syndrome (BrS), an arrhythmic disorder that is a …
Wnt/β-catenin signaling has been recently established. However, the role of Wnt/β-catenin …

… b | The most prevalent mutations associated with Brugada syndrome (BrS) occur in
genes that encode channels involved in the sodium (SCN5A and SCN10A) and calcium (CACN1A) …

… Downregulation of I Na , as occurs in Brugada syndrome (BrS), causes ventricular arrhythmias.
The present study investigated whether the Wnt/β-catenin signaling regulates Na v 1.5 in …

… Wnt/β-catenin signaling pathway plays essential roles in … a crucial role of Wnt/β-catenin
signaling in the molecular … data regarding the Wnt/β-catenin signaling contribution to AC …

… Genetic analysis revealed that SCN5A mutations cause inherited arrhythmogenic diseases,
including long QT syndrome, 1 Brugada syndrome, 2 and idiopathic ventricular fibrillation. …

… Shanghai score for diagnosis of Brugada syndrome and Modified Task Force criteria for
diagnosis of ARVC showing the diagnostic categories for the diagnosis of each disease. ARVC, …

… Brugada syndrome associated with SCN5A E1053K mutation. (… Human Brugada mutation
E1053K is located within these … associated with Brugada syndrome and Brugada syndrome is …

… Brugada hiPSC-CMs with shRNA-mediated β-catenin … Brugada hiPSC-CMs. Conclusions:
This study demonstrated Wnt-inhibition of human cardiac I Na and, using Brugada Syndrome …

… As the edges of the molecular complexes are blurred, so are the clinical syndromes that
associate with them: Brugada syndrome is not purely arrhythmogenic (but includes a structural …

… Yet, loss of function of the sodium channel has been primarily associated with the phenotype
of a different inherited arrhythmia, namely Brugada syndrome (BrS). Here, we speculate …