Mutation of Klotho rs3752472 protect the kidney from the renal epithelial cell injury caused by CaOx crystals through the Wnt/β-catenin signaling pathway
C Xu, W Zhang, P Lu, J Chen, Y Zhou, G Shen, Z Wang… - Urolithiasis, 2021 - Springer
… of CaOx crystals and the consequent renal epithelial cell injury through inhibiting the Wnt/β-catenin …
Our results supported the strong relationship between Klotho and the CaOx crystal’s …
Our results supported the strong relationship between Klotho and the CaOx crystal’s …
Inactivation of the Wnt/β-catenin signaling contributes to the epithelial barrier dysfunction induced by sodium oxalate in canine renal epithelial cells
Y Ji, S Fang, Y Yang, Z Wu - Journal of Animal Science, 2021 - academic.oup.com
… as a risk factor for renal calcium oxalate stones in companion animals (dogs and cats). …
formation of calcium oxalate stones. Also, exposure to oxalate or calcium oxalate crystals induces …
formation of calcium oxalate stones. Also, exposure to oxalate or calcium oxalate crystals induces …
Secreted products of macrophages exposed to calcium oxalate crystals induce epithelial mesenchymal transition of renal tubular cells via RhoA-dependent TGF-β1 …
R Kanlaya, K Sintiprungrat… - Cell biochemistry and …, 2013 - Springer
… We hypothesized that calcium oxalate (CaOx), a major crystalline component of kidney
stones, could induce secretion of fibrotic factors from macrophages leading to “epithelial …
stones, could induce secretion of fibrotic factors from macrophages leading to “epithelial …
[HTML][HTML] CAV1 alleviated CaOx stones formation via suppressing autophagy-dependent ferroptosis
Y Yang, S Hong, Y Lu, Q Wang, S Wang, Y Xun - PeerJ, 2022 - peerj.com
… To investigate the genes associated with CaOx stones formation, we examined the data
uploaded to the Gene Expression Omnibus (GEO) database (GSE73680), which performed a …
uploaded to the Gene Expression Omnibus (GEO) database (GSE73680), which performed a …
Calcium oxalate crystals induces tight junction disruption in distal renal tubular epithelial cells by activating ROS/Akt/p38 MAPK signaling pathway
L Yu, X Gan, X Liu, R An - Renal Failure, 2017 - Taylor & Francis
… Citation 1 Calcium oxalate monohydrate (COM) is the major crystalline composition of kidney
stone matrix, accounting for up to 70%.Citation 2 Adhesion of COM crystals to renal tubular …
stone matrix, accounting for up to 70%.Citation 2 Adhesion of COM crystals to renal tubular …
… development of the epithelial–mesenchymal transition and formation of a calcium oxalate crystal in renal tubular epithelial cells in mice with kidney stones via the PI3K …
XF Wang, BH Zhang, XQ Lu… - Journal of Cellular …, 2019 - Wiley Online Library
… regulation related genes, and the growth of calcium crystals … decreased and a number of
crystals reduced. Taken together, … of the calcium oxalate crystal in renal TECs of kidney stones …
crystals reduced. Taken together, … of the calcium oxalate crystal in renal TECs of kidney stones …
Vitexin exerts protective effects against calcium oxalate crystal-induced kidney pyroptosis in vivo and in vitro
T Ding, T Zhao, Y Li, Z Liu, J Ding, B Ji, Y Wang, Z Guo - Phytomedicine, 2021 - Elsevier
… The role of GSDMD in kidney stones has not been examined … treatment alleviated renal
crystal deposition and pathological … pyroptosis mediates calcium oxalate crystal-induced injury, …
crystal deposition and pathological … pyroptosis mediates calcium oxalate crystal-induced injury, …
Lamin A/C in renal tubular cells is important for tissue repair, cell proliferation, and calcium oxalate crystal adhesion, and is associated with potential crystal receptors
N Pongsakul, A Vinaiphat, P Chanchaem… - The FASEB …, 2016 - Wiley Online Library
… COM crystal … Crystal-binding assay highlighted the role of LMNA in crystal adhesion,
whereas protein network analysis revealed interactions between LMNA and potential COM crystal …
whereas protein network analysis revealed interactions between LMNA and potential COM crystal …
Calcium oxalate monohydrate crystal disrupts tight junction via F-actin reorganization
P Peerapen, V Thongboonkerd - Chemico-Biological Interactions, 2021 - Elsevier
… This study aimed to address whether COM crystal disrupts … treated with 100 μg/ml COM
crystals for 48 h. Western blot … of β-actin remained unchanged after exposure to COM crystals. …
crystals for 48 h. Western blot … of β-actin remained unchanged after exposure to COM crystals. …
Differential bound proteins and adhesive capabilities of calcium oxalate monohydrate crystals with various sizes
P Peerapen, V Thongboonkerd - International Journal of Biological …, 2020 - Elsevier
… However, effects of crystal size on the crystal adhesive capability remained … of CaOx
monohydrate (COM) crystals with various sizes (<10 μm, 20–30 μm, 50–60 μm, and > 80 μm). Crystal…
monohydrate (COM) crystals with various sizes (<10 μm, 20–30 μm, 50–60 μm, and > 80 μm). Crystal…
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