Activating Wnt/β-catenin signaling pathway for disease therapy: Challenges and opportunities
P Huang, R Yan, X Zhang, L Wang, X Ke… - Pharmacology & …, 2019 - Elsevier
… molecules that activated Wnt/β-catenin signaling pathway in various … Finally, we proposed
the challenges and opportunities in … We also proposed the challenges and opportunities in …
the challenges and opportunities in … We also proposed the challenges and opportunities in …
Targeting the Wnt/β-catenin pathway in neurodegenerative diseases: recent approaches and current challenges
A Serafino, D Giovannini, S Rossi… - Expert Opinion on Drug …, 2020 - Taylor & Francis
… We also discuss the opportunities that this signaling might offer for the therapy of these
pathologies, keeping in mind the potential drawbacks that such an approach might have, given …
pathologies, keeping in mind the potential drawbacks that such an approach might have, given …
Wnt/β-catenin signalling: function, biological mechanisms, and therapeutic opportunities
J Liu, Q Xiao, J Xiao, C Niu, Y Li, X Zhang… - Signal transduction and …, 2022 - nature.com
… trials of the Wnt/β-catenin signalling pathway in … /β-catenin pathway from the above five
aspects in combination with the latest research. Finally, we propose challenges and opportunities …
aspects in combination with the latest research. Finally, we propose challenges and opportunities …
Modulation of Wnt–β-catenin signaling with antibodies: therapeutic opportunities and challenges
… Since the recognition that mutations in components of the Wnt–β-catenin pathway underlie
… the Wnt–β-catenin pathway, and detail the advances and challenges in both cancer and …
… the Wnt–β-catenin pathway, and detail the advances and challenges in both cancer and …
[HTML][HTML] The regulation of β-catenin activity and function in cancer: therapeutic opportunities
S Shang, F Hua, ZW Hu - Oncotarget, 2017 - ncbi.nlm.nih.gov
… This review focuses on the regulation of β-catenin activity in the canonical Wnt/β-catenin …
challenges this model. They found no evidence of a direct interaction between β-catenin …
challenges this model. They found no evidence of a direct interaction between β-catenin …
A Wnt-ow of opportunity: targeting the Wnt/β-catenin pathway in breast cancer
JR Prosperi, KH Goss - Current drug targets, 2010 - ingentaconnect.com
… /βcatenin signaling offers a tremendous opportunity to impact breast cancer pathogenesis.
This review will provide an overview of the current understanding of Wnt/β-catenin … challenge …
This review will provide an overview of the current understanding of Wnt/β-catenin … challenge …
Wnt/β-catenin signaling in cancers and targeted therapies
F Yu, C Yu, F Li, Y Zuo, Y Wang, L Yao, C Wu… - … and Targeted Therapy, 2021 - nature.com
… Therefore, we sought to provide readers with the latest progress of Wnt/β-catenin signaling
in cancers and demonstrate both opportunities and challenges of Wnt/β-catenin signaling-…
in cancers and demonstrate both opportunities and challenges of Wnt/β-catenin signaling-…
Is β-catenin a druggable target for cancer therapy?
C Cui, X Zhou, W Zhang, Y Qu, X Ke - Trends in Biochemical Sciences, 2018 - cell.com
… small molecules that directly bind β-catenin, discuss the druggability of β-catenin, and why it
… small molecule binding and depleting cellular β-catenin, which are generally applicable to …
… small molecule binding and depleting cellular β-catenin, which are generally applicable to …
Targeting the Wnt/beta-catenin pathway in cancer: Update on effectors and inhibitors
N Krishnamurthy, R Kurzrock - Cancer treatment reviews, 2018 - Elsevier
The Wnt/beta-catenin pathway is a family of proteins that is implicated in many vital cellular
functions such as stem cell regeneration and organogenesis. Several intra-cellular signal …
functions such as stem cell regeneration and organogenesis. Several intra-cellular signal …
Wnt signaling in breast cancer: biological mechanisms, challenges and opportunities
X Xu, M Zhang, F Xu, S Jiang - Molecular cancer, 2020 - Springer
… Wnt signaling and breast cancer and provide an overview of existing mechanisms,
challenges, and potential opportunities for advancing the therapy and diagnosis of breast cancer. …
challenges, and potential opportunities for advancing the therapy and diagnosis of breast cancer. …
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