Activating Wnt/β-catenin signaling pathway for disease therapy: Challenges and opportunities

P Huang, R Yan, X Zhang, L Wang, X Ke… - Pharmacology & …, 2019 - Elsevier
… molecules that activated Wnt/β-catenin signaling pathway in various … Finally, we proposed
the challenges and opportunities in … We also proposed the challenges and opportunities in …

Targeting the Wnt/β-catenin pathway in neurodegenerative diseases: recent approaches and current challenges

A Serafino, D Giovannini, S Rossi… - Expert Opinion on Drug …, 2020 - Taylor & Francis
… We also discuss the opportunities that this signaling might offer for the therapy of these
pathologies, keeping in mind the potential drawbacks that such an approach might have, given …

Wnt/β-catenin signalling: function, biological mechanisms, and therapeutic opportunities

J Liu, Q Xiao, J Xiao, C Niu, Y Li, X Zhang… - Signal transduction and …, 2022 - nature.com
… trials of the Wnt/β-catenin signalling pathway in … /β-catenin pathway from the above five
aspects in combination with the latest research. Finally, we propose challenges and opportunities

Modulation of Wnt–β-catenin signaling with antibodies: therapeutic opportunities and challenges

S O'brien, R Chidiac, S Angers - Trends in Pharmacological Sciences, 2023 - cell.com
… Since the recognition that mutations in components of the Wnt–β-catenin pathway underlie
… the Wnt–β-catenin pathway, and detail the advances and challenges in both cancer and …

[HTML][HTML] The regulation of β-catenin activity and function in cancer: therapeutic opportunities

S Shang, F Hua, ZW Hu - Oncotarget, 2017 - ncbi.nlm.nih.gov
… This review focuses on the regulation of β-catenin activity in the canonical Wnt/β-catenin
challenges this model. They found no evidence of a direct interaction between β-catenin

A Wnt-ow of opportunity: targeting the Wnt/β-catenin pathway in breast cancer

JR Prosperi, KH Goss - Current drug targets, 2010 - ingentaconnect.com
… /βcatenin signaling offers a tremendous opportunity to impact breast cancer pathogenesis.
This review will provide an overview of the current understanding of Wnt/β-cateninchallenge

Wnt/β-catenin signaling in cancers and targeted therapies

F Yu, C Yu, F Li, Y Zuo, Y Wang, L Yao, C Wu… - … and Targeted Therapy, 2021 - nature.com
… Therefore, we sought to provide readers with the latest progress of Wnt/β-catenin signaling
in cancers and demonstrate both opportunities and challenges of Wnt/β-catenin signaling-…

Is β-catenin a druggable target for cancer therapy?

C Cui, X Zhou, W Zhang, Y Qu, X Ke - Trends in Biochemical Sciences, 2018 - cell.com
… small molecules that directly bind β-catenin, discuss the druggability of β-catenin, and why it
… small molecule binding and depleting cellular β-catenin, which are generally applicable to …

Targeting the Wnt/beta-catenin pathway in cancer: Update on effectors and inhibitors

N Krishnamurthy, R Kurzrock - Cancer treatment reviews, 2018 - Elsevier
The Wnt/beta-catenin pathway is a family of proteins that is implicated in many vital cellular
functions such as stem cell regeneration and organogenesis. Several intra-cellular signal …

Wnt signaling in breast cancer: biological mechanisms, challenges and opportunities

X Xu, M Zhang, F Xu, S Jiang - Molecular cancer, 2020 - Springer
… Wnt signaling and breast cancer and provide an overview of existing mechanisms,
challenges, and potential opportunities for advancing the therapy and diagnosis of breast cancer. …