Nuclear translocation of β-catenin is essential for glioma cell survival

Z Shi, X Qian, L Li, J Zhang, S Zhu, J Zhu… - Journal of Neuroimmune …, 2012 - Springer
… of nuclear β-catenin suppresses glioblastoma cell viability and proliferation and induces
apoptosis. a Confocal microscope analysis of β-catenin location in LN229 and U87 cells after …

βCatenin Signalling in Glioblastoma Multiforme and Glioma‐Initiating Cells

M Nager, D Bhardwaj, C Cantí, L Medina… - Chemotherapy …, 2012 - Wiley Online Library
… of Wnt/β-catenin signalling in glioma initiation, proliferation, and invasion. Understanding
the molecular mechanisms regulating GIC biology and glioma … and improve patient survival. …

β-Catenin overexpression in malignant glioma and its role in proliferation and apoptosis in glioblastma cells

X Liu, L Wang, S Zhao, X Ji, Y Luo, F Ling - Medical Oncology, 2011 - Springer
… In this study, the expression of β-catenin in astrocytic glioma tissues … level of β-catenin in
astrocytic glioma patients with high … in the regulation of cell growth, proliferation and survival [19–…

R132H mutation in IDH1 gene reduces proliferation, cell survival and invasion of human glioma by downregulating Wnt/β-catenin signaling

D Cui, J Ren, J Shi, L Feng, K Wang, T Zeng… - … of biochemistry & cell …, 2016 - Elsevier
… /β-catenin activity in IDH1-R132H glioma cells, we performed a microarray-based analysis
of differential gene expression between IDH1-R132H and IDH1-wt overexpressing U87 cells. …

[HTML][HTML] LGR5, a novel functional glioma stem cell marker, promotes EMT by activating the Wnt/β-catenin pathway and predicts poor survival of glioma patients

J Zhang, H Cai, L Sun, P Zhan, M Chen… - Journal of experimental …, 2018 - Springer
… expression identifies a subset of glioma patients with a poorer survival profile than LGR5
low expression might provide aid for clinicians in determining the prognosis of glioma patients. …

Wnt/beta-catenin signaling in glioma

K Zhang, J Zhang, L Han, P Pu, C Kang - Journal of Neuroimmune …, 2012 - Springer
… of beta-catenin/TCF4 signaling in glioblastoma cells. In vivo binding of beta-catenin/TCF4 to
… to suppress beta-catenin/TCF4 activity, thereby inhibiting glioma cell survival and inducing …

α-Catenin inhibits glioma cell migration, invasion, and proliferation by suppression of β-catenin transactivation

H Ji, J Wang, B Fang, X Fang, Z Lu - Journal of neuro-oncology, 2011 - Springer
… However, whether α-catenin expression contributes to β-catenin transactivation in glioma
cells is largely unknown. We report here that α-catenin expression abrogates epidermal growth …

[HTML][HTML] Wnt/β-catenin signaling pathway inhibits the proliferation and apoptosis of U87 glioma cells via different mechanisms

L Gao, B Chen, J Li, F Yang, X Cen, Z Liao, X Long - PloS one, 2017 - journals.plos.org
… The Hippo signaling pathway is involved in cell survival, proliferation, differentiation, and
organ development. This pathway is also one of the tumor suppressor pathways [44,45]. …

Wnt/βcatenin signaling cascade: A promising target for glioma therapy

L He, H Zhou, Z Zeng, H Yao… - Journal of cellular …, 2019 - Wiley Online Library
… and inhibits apoptotic cell death of glioma cell by enhancing Wnt/β-catenin pathway. Conversely…
agonists pioglitazone suppresses cell viability and proliferation of GSCs, partly via Wnt/β-…

Downregulation of Wnt2 and β-catenin by siRNA suppresses malignant glioma cell growth

P Pu, Z Zhang, C Kang, R Jiang, Z Jia, G Wang… - Cancer gene …, 2009 - nature.com
Glioma cell viability, invasion and apoptosis were affected by transfection with Wnt2 or β-catenin
siRNA. (a) Cell viability of U251 cells transfected with scramble, Wnt2 or …