… We show that loss of Klotho de-represses Wnt/β-catenin signaling because Klotho physically
binds to and sequesters Wnt ligands in the kidneys. This leads to activation of a fibrogenic …

… The over-expression of β-catenin in mature … of Klotho in chondrocytes in OA also lost its
antagonistic effect on Wnt1, 4 and 7a, which resulted in relative activation of Wnt/β-catenin and …

… occurs during the late phase of cervical tumorigenesis, and consequent functional loss of
klotho contributes to aberrant activation of the canonical Wnt pathway. Therefore, we …

… There were no differences in the renal expression of Klotho, suggesting that the lower serum
sKlotho found in the diabetic rats could be due to urinary loss as consequence of polyuria (…

… In summary, this is the first report about the role of klotho in ESCC and its association with
β-catenin. We confirm that low expression of klotho occurs frequently in ESCC, and its loss …

… Our study demonstrated that transplantation of Klotho-GFP-BMSCs into IRI mice ameliorated
the loss of renal function and renal interstitial fibrosis, and the renal protective effect of …

… Therefore, KL-/- mice and klotho mutant mice are collectively described as Klotho-deficient …
Despite the lack of Klotho expression in the kidney, the EFmKL48 allele was able to rescue …

… RT-PCR and western blotting analysis were used to detect the expression of Klotho, β-catenin…
Colony formation assay was used to test the proliferation ability in Klotho transfected cells. …

… can predict the prognosis of nephropathy in type 2 diabetic patients, 16 , 17 suggesting that
loss of Klotho may have a causative role in the pathogenesis and progression of DKD. More …

… The loss of Klotho during kidney … Klotho is reduced already in stage I human CKD suggests
that there are factors that reduce Klotho synthesis by tubular epithelium beyond the loss of …