… of soluble Klotho in inhibiting renal fibrosis and fibrosis in distant organs secondary to renal
Klotho deficiency. We also discuss the structure-function relationships of Klotho domains …

… As a potential mechanism, we provided evidence that α-klotho inhibits TGF-β receptor
binding, decreases cytosolic and mitochondrial oxidative stress by attenuating NOX4 and …

… Interestingly, LF treatment downregulated Wnt4/β-catenin signaling and increased both
renal klotho gene expression and serum klotho level. Furthermore, LF treatment reduced …

… of β-catenin targets in response to TGF-β1. Invivo expression of secreted Klotho in inhibits
the activation of renal β-catenin… that Klotho is an endogenous antagonist of Wnt and β-catenin …

… between Wnt/β-catenin signaling and regulation of Klotho and FGF23 36 . In this study, the
Klotho protein and … Moreover, Klotho induces activation of DR4/5 death receptor signaling. …

Objective We aimed to evaluate the prognostic performance of circulating Klotho in
coronary atherosclerotic disease (CAD), and to further explore the effect of Klotho on stress-mediated …

… deficient mice also display high FGF23 levels (40), and as a consequence of loss of Klotho
expression may result in maladaptive signaling downstream of the FGF-receptor (FGFR) that …

… Klotho protein-Wnt signaling pathway. Following immunohistochemistry and ELISA, we
treated cells with Klotho … hypogonadism, neurodegeneration, and hearing loss [2]. Additionally, …

… Klotho, circulating soluble Klotho expectedly declines as CKD progresses (Figure 3).
Decreased Klotho expression in CKD is not simply due to loss of … of the Klotho gene promoter by …

… The factors that lead to elevated levels of circulating klotho in these cancer patients, and
the reason for the lack of effect on cancer cell proliferation, are still unknown and more studies …