… of progenitor cells and the developmental pathways of endocrine cells. Heterogeneity can
also … owing to β-cell plasticity or changes in islet architecture. Furthermore, β-cell neogenesis, …

… Our findings showing marked diversity in islet architecture between islets from a single …
, between islet architecture and the pattern of blood flow within the islet. Islet plasticity under …

… size (limited to ~500 µm in diameter) throughout mammals that we have studied,Citation
9 , Citation 10 the increased ratio of non-β cells and intermingled architecture suggests an …

… Islet architecture is disrupted in rodent diabetic models, diabetic primates and human Type
… an increased α-cell population and relocation of non-β-cells to central areas of the islet. In …

… the leptin receptor, islet architecture and cellular composition resemble that of humans. Here
we review pancreatic islet architecture and endocrine cell composition from fish to humans. …

… examined β cell function and expression of additional β cell … of islets to secretagogs indicated
a partial loss of β cell … associated with mature functional β cells: the transcription factors …

… , ECAD plays an essential role in allowing βcells to cluster in to islet structures [13]. Over-…
in mouse β-cells (the gene responsible for type 3 MODY) results in abnormal islet architecture, …

… The pancreatic islets exhibited abnormal architecture with … –mediated cell adhesion in
pancreatic islets abolished the … that loss of E-cadherin in β-cells is associated with impaired insulin …

… in α cells has no effect on islet architecture, implying that β cells … to electrical β cell-β cell
coupling, islet architecture also … signals within the islet, and these in turn affect islet function. …

… islets. Sections of mouse pancreas showing (a) a single islet stained with a cocktail of antibodies
to non-β-cells (stain … the anatomical architecture of the islet, it is likely that the β-cell also …