… 'dialog' between invading immune cells and the target β cells. This dialog is mediated … β
cells and immune cells, and by putative, immunogenic signals that are delivered by dying β cells. …

… In the recently completed Diabetes Prevention Trial (DPT)-1, a prospective study of … type 1
diabetes, ∼3.7% of relatives of type 1 diabetic patients have islet cell autoantibodies (ICAs) (1)…

… Our studies of β-cell mass in NOD mice at diagnosis of type 1 diabetes are consistent with
this notion. As noted above, there was a significant increase in β-cell area after treatment with …

… diabetes, is a chronic disease characterized by insulin deficiency due to pancreatic β-cell …
is thought to involve T cell-mediated destruction of β-cells. Islet-targeting autoantibodies that …

… increased β-cell replication during the development of type 1 diabetes in … β-cell mass.
Unlike NOD/scid and other mice in which β-cell replication decreased with age, the rates of β-cell …

… but limited inverse correlation with diabetes duration (r = −… β-cells were observed in all type
1 diabetes donors with insulitis, while β-cell area and mass were significantly higher in type 1 …

… the pancreas is devoid of insulin-producing cells and the remaining β cells are incapable of
regeneration. Both of these concepts of pathogenesis of type 1 diabetes have been debated. …

… What once seemed like a single autoimmune disorder, with roots in T-cell mediated attack
of insulin-producing β cells, is now recognised to result from a complex interplay between …

… complex nature of type 1 diabetes, the likelihood that this disorder may represent a disease
with more than one etiology, as … One limitation in solving important pathogenic questions in …

… Type 1 diabetes mellitus (T1DM) arises when the pancreatic β cells undergo long-term … ,
killing the majority of the β-cell population while the neighbouring α cells and δ cells are spared …