… and amplifying signals in β cells and stimulation of insulin secretion. The triggering signal …
]i changes in β cells, and the amplifying signal as the increase in insulin secretion produced by …

… also exert an important level of control over insulin secretion and ultimately glucose
homeostasis. For example, glucagon secreted from islet alpha cells potentiates insulin secretion ( …

… Understanding the response of pancreatic beta cells to increased amounts of fuel and the
role that altered insulin secretion plays in the development and maintenance of obesity and …

… We highlight salient differences between mouse and human β-cells, provide models of how
the … Much of our knowledge of insulin secretion comes from work on rodent islets and β-cells. …

… in terms of insulin secretion also exists between human beta cells and how insulin secretion
is … were dissociated and insulin secretion from single beta cells and aggregated cell pairs …

… cells are the only cell type in our body capable of producing and secreting insulin to instruct
the insulin-sensitive cells … of insulin release is of critical importance; too little insulin leads to …

The β-cell is unique because its major agonists, ie, insulin … specific to the secretagogue and
the β-cell and can be envisioned as … in the β-cell operate the same as in other cells. Aerobic …

… β-cells are sensitive to oxidative stress, excessive ROS may cause dysfunction of β-cells. …
suppress glucose-induced insulin secretion (GIIS) from β-cells. Intracellular ROS increased 15 …

… that FFAs markedly amplified insulin secretion in response to all fuel … β-cell signaling
processes, in particular those involving lipid signaling. Thus, we recommend that insulin secretion …

… β-cell function and, in particular, in glucose sensing. Moreover, models of β-cell ablation in
rodents suggest that non-β cells … express insulin and to respond to glucose with the secretion …