… are new β-lactamase inhibitors that are being studied in combination with β-lactams. Clinical
and … β-Lactam antibiotics are a mainstay for the treatment of many infections. The addition of …

… to describe the efficacy of all β-lactamase inhibitors (16). … As hydrophilic drugs, β-lactams
and β-lactamase inhibitors … the disposition of both β-lactams and β-lactamase inhibitors (18). …

… combination with the β-lactamase inhibitors covered in this review. The first generation of
β-lactamase inhibitors … 4-tazobactam combinations. However, the spectrum of activity of these …

… The use of β-lactamase inhibitors in combination with β-lactam … of respective inhibitors to
inactivate a wide range of β-lactamases … infections, especially in combination with other agents. …

… ESBL producers might be susceptible to β-lactam-β-lactamase inhibitor (BLBLI) combination
antibiotics such piperacillin–tazobactam or amoxicillin–clavulanate. These drugs are …

… Combinations of β-lactams and β-lactamase inhibitors have become one of the most …
generation β-lactamase inhibitors capable of encompassing both class A and class C β-lactamases …

… of a combination of a /Mactamase-inhibitor with a /J-lactam antibiotic Ideally, the inhibitor
must … must not be handicapped by a combination with an extremely labile /Mactam compound …

… presented data on a combination of the broad-spectrum β-lactamase inhibitor RPX7009 (a
novel boronate compound). RPX7009 appears active against class A β-lactamases, including …

… novel BL-β-lactamase inhibitor (BLI) combinations to target β-lactamase-mediated resistant
… , and preclinical BL-BLI combinations to target serine β-lactamases produced by Gram-…

… β-lactamase families and various BLI combinations that have been developed or are under
development. Recently approved inhibitor combinations include the inhibitors … acid inhibitor …