… -lactamases stored in major public repositories into classes. We then mainly focus on the
Class A beta-lactamases as … It is widely used in computational biology due to its speed and the …

… the area of β-lactamase inhibitors promise to enable some β-lactamase-mediated resistance
to be overcome. A particular interest is the interactions of β-lactamases with carbapenems, …

… enzymes hydrolyzing all the β-lactam antibiotics but not monobactams. … β-lactam antibiotics
docking investigations and the related MBLs achievements throughout computational biology …

… of β-lactamase can be directly predicted by thermodynamic folding and binding free
energies. We focus upon β-lactamase … and computational free energies are of TEM-1 β-lactamase …

… for computational protein design, to calculate changes in the stability of mutant β-lactamase
·… the stability of the β-lactamase ·BLIP complexes and computationally assisted design of …

… β-lactamase are the main resistance factor for β-lactam antibiotics in Gram-negative bacteria.
Since β-lactam … a large number of β-lactam-inactivating β-lactamases have been produced …

… the β-lactamases is an important step towards the development of new potent inhibitors. Here,
we use computational … The TEM-1 β-lactamase/BLIP complex has been well studied both …

… β-Lactamases (BLs) able to hydrolyze β-lactam … β-lactamase (K i = 27 nM), we have
identified and characterized a set of BZB analogues able to inhibit clinically-relevant β-lactamases, …

… of β-lactamases and penicillin-binding proteins (PBPs). β-Lactamases are bacterial resistance
enzymes to β-lactam … PBPs gave rise to those of β-lactamases. PBPs process the building …

… bonds in maintaining the conformational stability of β-lactamases. Our results show that most
of … of β-lactamases. These findings may be helpful for medicinal and computational protein …