… the area of β-lactamase inhibitors promise to enable some β-lactamase-mediated resistance
to be overcome. A particular interest is the interactions of β-lactamases with carbapenems, …

… Like most antibiotics, β-lactam resistance can occur through multiple molecular mechanisms
including prevention of drug penetration into the cell, active efflux, target alteration to non-…

… as drug inactivation or modification by β-lactamases, alteration of binding sites, alteration
of metabolic pathways, and decreased permeability or increased efflux across the membrane. …

… the β-lactamase-mediated resistance: (i) New β-lactam drugs have been developed that
are less favorable substrates for many common β-lactamases, so-called extended-spectrum β-…

… of β-lactam drugs. By … β-lactamases, namely carbapenemases, which hydrolyze
carbapenem antibiotics. In all classes A to D, based on molecular structural classification, β-lactamases …

… dubbed the 'miracle drug', has been greatly compromised by beta-lactamases. The
problem … For instance, a series of mercaptoacetic acid thiol esters, molecules with non-beta-lactam …

… β-lactamase or molecules that were stable to β-lactamases … known β-lactamases in the
mid-1970s, TEM-stable molecules… β-lactams and clinically overused β-lactam-containing drugs …

… The β-lactam drugs have been the cornerstone of antibiotic therapy for such infections. …
the molecular mechanisms and epidemiology of β-lactamase-mediated β-lactam resistance in …

… The present review summarizes key structural, molecular and functional aspects of ESBL,
IRT and CMT TEM -lactamases properties and up to date diagrams of the TEM variants with …

… β-lactam ring composed of four atoms in a drug molecule. The four-membered ring of β-lactam …
ring makes the chemical properties of such drugs unstable. For instance, the ring is easily …