… sets of β-lactamases. In this minireview, a short history of the β-lactamases is presented,
emphasizing key points that have driven both academic and pharmaceutical science over the …

In this study, 121 Escherichia coli samples isolated from clinical specimens obtained from
Pakistan Institute of Medical Science, Islamabad, Pakistan, were analyzed for extended-…

… through establishing a simplified β-lactamase terminology for clinical and … β-lactamases
is a matter of great concern for all healthcare professionals—not just for β-lactamase scientists…

… This work provides a comprehensive overview of β-lactam antibiotics that are currently in
use, as well as a look ahead to several new compounds that are in the development pipeline. …

… β-lactamase (EC 3.5.2.6) described in the scientific literature, leading to the study of
thousands of similar enzymes now known to be responsible for most resistance to the β-lactam …

… A distinction must be made between AmpC βlactamases and ESBL enzymes. The AmpC
βlactamases are encoded by genes located on chromosomes, are often inducible, and are …

… Over the past 20 years, various β-lactamase descriptions have commonly included the
term ‘… β-lactamase’, or ESBL, to describe functional group 2be or molecular class A β-lactamases …

… of β-lactams has induced dynamic and continuous production and mutation of β-lactamases
in these bacteria, expanding their activity even against the newly developed β-lactam …

… the area of β-lactamase inhibitors promise to enable some β-lactamase-mediated resistance
to be overcome. A particular interest is the interactions of β-lactamases with carbapenems, …

… -interactive proteins, notably, the β-lactamases. The compounds highlighted in this review
were either designated as lead compounds in the scientific literature or meeting abstracts by …