… The current classification of β-lactamases into four molecular classes is based on motifs
involved in binding and hydrolysis, such as 70 SXXK, 130 SDN, and 234 KTG for class A (17), …

… Functional group 2 β-lactamases, including molecular classes A and D, represent the
largest group of β-lactamases, due primarily to the increasing identification of ESBLs during the …

… Functional group 2 molecular class A β-lactamases are the most abundant, with >550
enzymes, including numerous variants (8). As a support to an updated classification, a large …

… unrelated to the class A enzymes. It is predicted that sequence analysis will show that …
classes will need to be created to account for particular P-lactamases of distinctive molecular and …

… -lactamases belonging to all molecular classes are described in Tables 2 to 12, with separation
into groups based primarily on published functional characteristics. The strategy used for …

… contain an active-site serine that also can be acylated by β-lactam molecules, it is not
unexpected to find mechanistic and structural similarities between the two sets of enzymes (28, 29)…

… classes, labelled A, B, C and D. Class A, C and D β-lactamases use a catalytically active
serine residue for inactivation of the β-lactam drug, 6 whereas the molecular class B enzymes …

… lactamases and its correlation with molecular structure. Antimicrob parameters of class B
b-lactamases… carrying plasmids coding for class B b-lactaclass B b-lactamase gene (ccrA) from …

… alternative acylation mechanisms for class A β-lactamases. (a… upon the β-lactam carbonyl
by Glu166 via a water molecule (… Glu166 via a conserved water molecule and identify Lys73 as …

… Large numbers of β-lactamases have been identified and, in combination with easy
access to WGS and molecular techniques, the archiving of the identified β-lactamases has …