Despite refinements in histologic criteria for the diagnosis of endometrioid precancers, many
challenging cases are encountered in daily practice, creating diagnostic uncertainty and
suboptimal patient management. Recently, an immunohistochemical 3-marker panel
consisting of β-catenin, Pax2, and Pten was identified as a useful diagnostic adjunct.
However, previous studies focused either on cancers or diagnostically unambiguous
precancers, leaving questions about the applicability and utility of the panel in endometria …