Phytosphingosine in combination with ionizing radiation enhances apoptotic cell death in radiation-resistant cancer cells through ROS-dependent and-independent …

MT Park, MJ Kim, YH Kang, SY Choi, JH Lee, JA Choi… - Blood, 2005 - ashpublications.org
… T cells but failed to induce cell death in clone nos. 1, 6, 11, and 16 at 48 hours after γ-irradiation. …
pathways to induce cell death in the γ-radiation-resistant cells, we treated NAC to the …

Modeling radiation injury-induced cell death and countermeasure drug responses in a human Gut-on-a-Chip

S Jalili-Firoozinezhad, R Prantil-Baun, A Jiang… - Cell death & …, 2018 - nature.com
… analyze the effects of γ-radiation on villus morphology, barrier function, cellcell junctions, …
junction proteins, ZO-1 and VE-cadherin, in the irradiated epithelial and endothelial cells, …

The use of gamma-irradiation and ultraviolet-irradiation in the preparation of human melanoma cells for use in autologous whole-cell vaccines

DH Deacon, KT Hogan, EM Swanson… - BMC cancer, 2008 - Springer
… incorporating little 3 H-thymidine are unlikely to be undergoing mitosis at a high rate and
thus less likely to acquire the genomic instability necessary to lead to cell death. Although less …

LKB1 loss is associated with glutathione deficiency under oxidative stress and sensitivity of cancer cells to cytotoxic drugs and γ-irradiation

E Zulato, F Ciccarese, V Agnusdei, M Pinazza… - Biochemical …, 2018 - Elsevier
… Evaluation of cell death in γ-irradiated cells after 48 h in absence or presence of NAC (16
h pre-treatment). Results are reported as mean values ± SD and are representative of three …

Homologous recombination is responsible for cell death in the absence of the Sgs1 and Srs2 helicases

S Gangloff, C Soustelle, F Fabre - Nature genetics, 2000 - nature.com
… This result does not contradict the conclusion that repair between sisters is unaffected in
sgs1Δ mutants alone after γ-ray irradiation, but underscores the difference between the cellular

Caffeine-suppressed ATM pathway leads to decreased p53 phosphorylation and increased programmed cell death in gamma-irradiated leukaemic molt-4 cells

A Tichý, D Muthná, J Vávrová, J Pejchal… - Journal of applied …, 2011 - Elsevier
… Besides providing the evidence that caffeine inhibits ATM-dependent phosphorylation of
p53 in γ-irradiated leukaemic cells we also report on the inhibition of p21. This protein functions …

Loss of the BH3-only protein Bmf impairs B cell homeostasis and accelerates γ irradiation–induced thymic lymphoma development

V Labi, M Erlacher, S Kiessling, C Manzl… - The Journal of …, 2008 - rupress.org
γ irradiation–… γ irradiation protocol and monitored the development of thymic lymphomas
over time. Interestingly, loss of Bmf delayed cell death of thymocytes in response to γ irradiation

Flow cytometry and biochemical analysis of DNA degradation characteristic of two types of cell death

VN Afanas' ev, BA Korol, YA Mantsygin, PA Nelipovich… - FEBS letters, 1986 - Elsevier
… the 2 types of cell death. Thymocytes of irradiated or glucocorticoid-treated rats were used as
cells dying by apoptosis… Dividing cells usually undergo necrosis upon y-irradiation. And so …

Cell-cycle arrest versus cell death in cancer therapy

T Waldman, Y Zhang, L Dillehay, J Yu, K Kinzler… - Nature medicine, 1997 - nature.com
… This work suggested that clonogenic cells can more efficiently populate a tumor … " cells than
in the context of frank cell death. Perhaps the few clonogenic cells remaining after irradiation

c-Myc augments gamma irradiation-induced apoptosis by suppressing Bcl-XL

KH Maclean, UB Keller… - … and cellular biology, 2003 - Am Soc Microbiol
Cells were then analyzed for the presence of apoptotic cells by FACS analysis. To detect cell
death in B cells derived from untreated or treated (2-Gy γ… (5 × 10 4 cells) with the terminal …