γ-Oryzanol alleviates acetaminophen-induced liver injury: roles of modulating AMPK/GSK3β/Nrf2 and NF-κB signaling pathways
G Shu, Y Qiu, J Hao, Q Fu, X Deng - Food & function, 2019 - pubs.rsc.org
Acetaminophen (APAP) overdose is a major cause of drug-induced liver injury worldwide.
Our current study was performed to assess the potential protective effects of γ-oryzanol
(ORY) on APAP-induced liver injury in mice and explore the underlying molecular
mechanisms. We unveiled that ORY alleviated the APAP-induced death of HL-7702
hepatocytes in vitro and liver injury in mice. Moreover, ORY promoted the nuclear
translocation of Nrf2, increased the expressions of Nrf2-downstream antioxidative enzymes …
Our current study was performed to assess the potential protective effects of γ-oryzanol
(ORY) on APAP-induced liver injury in mice and explore the underlying molecular
mechanisms. We unveiled that ORY alleviated the APAP-induced death of HL-7702
hepatocytes in vitro and liver injury in mice. Moreover, ORY promoted the nuclear
translocation of Nrf2, increased the expressions of Nrf2-downstream antioxidative enzymes …
γ-Oryzanol alleviates acetaminophen-induced liver injury: roles of modulating AMPK/GSK3β/Nrf2 and NF-κB signaling pathways.
SGW Shu GuangWen, QYH Qiu YunHan, HJ Hao Ji… - 2019 - cabidigitallibrary.org
Acetaminophen (APAP) overdose is a major cause of drug-induced liver injury worldwide.
Our current study was performed to assess the potential protective effects of γ-oryzanol
(ORY) on APAP-induced liver injury in mice and explore the underlying molecular
mechanisms. We unveiled that ORY alleviated the APAP-induced death of HL-7702
hepatocytes in vitro and liver injury in mice. Moreover, ORY promoted the nuclear
translocation of Nrf2, increased the expressions of Nrf2-downstream antioxidative enzymes …
Our current study was performed to assess the potential protective effects of γ-oryzanol
(ORY) on APAP-induced liver injury in mice and explore the underlying molecular
mechanisms. We unveiled that ORY alleviated the APAP-induced death of HL-7702
hepatocytes in vitro and liver injury in mice. Moreover, ORY promoted the nuclear
translocation of Nrf2, increased the expressions of Nrf2-downstream antioxidative enzymes …
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