… opioids, more specifically morphine, on tumor growth and metastasis which are mediated by
a combination of direct effects on tumor … to express functional μ-opioid receptor. Mechanistic …

… of opioids would possibly facilitate tumor growth, however, in the context of pain and distress,
which is known to promote tumor … of opioids and in particular their impact on tumor growth …

… the possible role of opioids in tumor progression, with a focus on the μ-opioid receptor (MOR…
opioids may play an important role in tumor growth and metastasis. Endogenous opioids …

… /ml epidermal growth factor (conditions we previously established to produce optimal H358
tumor growth) and injected subcutaneously into the flank of Ncr-nude mice. Tumor nodules …

… and demonstrated inhibition of tumor growth and metastasis (Fig… lung tumor growth in mice
by 2-fold (P =.009) (Fig. 3).25 … tumor growth in the nude mice, with a 2.5-fold increase noted in …

… and that use of opioids in in vivo animal cancer models does not promote tumor growth. For
… The upregulation of µ-opioid receptor (MOR) in lung cancer samples with metastasis was …

… Importantly, our observations of attenuation of tumor growth and metastasis occurred absent
… In conjunction with our findings that μ opioids alter endothelial barrier integrity and facilitate …

… Currently, research studies aiming to reduce side effects of opioids promoting tumor growth
by using opioids in combination with MNTX are underway [32]. This will also be a main focus …

… increased tumor growth and metastasis, this study examined whether MOR regulates growth
factor … Our results indicate MOR regulates opioid and growth factor-induced EGF receptor …

… reduction in tumor growth To investigate possible effects of μ-opioids on tumor growth in …
mice developed subcutaneous tumors, whereas macroscopic tumor growth was observed …