Abstract 1H-1, 2, 3-triazole tethered isatin-ferrocene conjugates were synthesized and
evaluated for their antiplasmodial activities against chloroquine-susceptible (3D7) and
chloroquine-resistant (W2) strains of Plasmodium falciparum. The conjugates 5f and 5h with
an optimum combination of electron-withdrawing halogen substituent at C-5 position of
isatin ring and a propyl chain, introduced as linker, proved to be most potent and non-
cytotoxic among the series with IC 50 values of 3.76 and 4.58 μM against 3D7 and W2 …

Abstract 1 H-1, 2, 3-triazole tethered isatin-ferrocene conjugates were synthesized and
evaluated for their antiplasmodial activities against chloroquine-susceptible (3D7) and
chloroquine-resistant (W2) strains of Plasmodium falciparum. The conjugates 5f and 5h with
an optimum combination of electron-withdrawing halogen substituent at C-5 position of
isatin ring and a propyl chain, introduced as linker, proved to be most potent and non-
cytotoxic among the series with IC50 values of 3.76 and 4.58 µM against 3D7 and W2 …