Morphological and molecular alterations in 1, 2 dimethylhydrazine and azoxymethane induced colon carcinogenesis in rats

M Perše, A Cerar - BioMed Research International, 2011 - Wiley Online Library
colon carcinogenesis. It has many morphological as well as molecular similarities to human
sporadic colorectal cancer (CC), … that occur in the colonic mucosa when evaluating natural or …

Coriandrum sativum—effect on lipid metabolism in 1, 2-dimethyl hydrazine induced colon cancer

V Chithra, S Leelamma - Journal of ethnopharmacology, 2000 - Elsevier
… on lipid parameters in 1,2-dimethyl hydrazine (DMH) induced colon cancer in rats were studied.
The … role against the deleterious effects in lipid metabolism in experimental colon cancer. …

Biochemical and molecular aspects of 1, 2-dimethylhydrazine (DMH)-induced colon carcinogenesis: a review

K Venkatachalam, R Vinayagam… - Toxicology …, 2020 - academic.oup.com
… a carcinogen to induce colon cancer in animal models. Exploration of DMH-induced colon
carcinogenesis in … of different stages of colon carcinogenesis. The procarcinogen DMH, after a …

Chemoprevention of 1, 2-dimethylhydrazine-induced colon cancer in mice by naturally occurring organosulfur compounds

H Sumiyoshi, MJ Wargovich - Cancer research, 1990 - AACR
… garlic, inhibited DMH-induced nuclear aberrations and tumors in the mouse colon in a dose-…
is the essential in inhibition of DMH-induced colon carcinogenesis. Ajoene con tains an allyl …

Chemopreventive efficacy of ginger, a naturally occurring anticarcinogen during the initiation, post-initiation stages of 1, 2 dimethylhydrazine-induced colon cancer

V Manju, N Nalini - Clinica Chimica Acta, 2005 - Elsevier
… ,2-Dimethylhydrazine (DMH) is a potent carcinogen that has been reported to induce colon
cancer … Experimental colon cancer induced by DMH in rats is a prolonged multistage process, …

The effect of rosmarinic acid on 1, 2-dimethylhydrazine induced colon carcinogenesis

K Venkatachalam, S Gunasekaran… - Experimental and …, 2013 - Elsevier
… used 1,2-dimethylhydrazine (DMH), a cycasin derivative to induce colon cancer in rats. This
… disease, during the development of colon cancer. DMH is converted to azoxymethane (AOM)…

Chemopreventive efficacy of gallic acid, an antioxidant and anticarcinogenic polyphenol, against 1, 2-dimethyl hydrazine induced rat colon carcinogenesis

JS Giftson, S Jayanthi, N Nalini - Investigational new drugs, 2010 - Springer
… and cancer development, its effect on colon carcinogenesis in vivo, is not yet documented.
In this investigation we have delineated the role of GA on DMH induced colon carcinogenesis

Investigations into the metabolism and mode of action of the colon carcinogens 1, 2dimethylhydrazine and azoxymethane

ES Fiala - Cancer, 1977 - Wiley Online Library
carcinogen involved in human colon cancer be considered, azoxymethane would be a more
likely choice, in our opinion, than 1,2-dimethylhydrazine. … by the intestinal microbial flora or …

Effect of gallic acid on xenobiotic metabolizing enzymes in 1, 2-dimethyl hydrazine induced colon carcinogenesis in Wistar rats–a chemopreventive approach

JG Senapathy, S Jayanthi, P Viswanathan… - Food and chemical …, 2011 - Elsevier
… and cancer development, its effect on colon carcinogenesis in … induced colon carcinogenesis
in rats with special focus on phase I [cytochrome P450 and cytochrome b5] and phase II […

Effects of aspirin on 1, 2-dimethylhydrazine-induced colonic carcinogenesis

PA Craven, FR DeRubertis - Carcinogenesis, 1992 - academic.oup.com
… of colon cancer (19-23). One of the goals of the present study was to determine whether 1,2-DMH-induced
colon cancer was altered by a dose of ASA that clearly suppressed colonic