The International Embryo Technology Society (IETS) Data Retrieval Committee presents the 31st annual report of data collected globally in 2022 on embryo transfer (ET) activities during the year 2021. As highlighted in the last report, in spite of the social and economic consequences of the COVID-19 pandemic, which was still a major global health issue in 2021, the general trends of the embryo industry were very positive around the world. Minor changes have been observed in the number of countries reporting ET data in 2021, which remained approximately 20%(40 of 195, 20.5%; Table 1). This stability reflects the consistency in data retrieval from countries within the Americas and Europe, but also the lack of more comprehensive information gathered from African and Asian countries. Nevertheless, we were able to use embryo export data to infer about the activity in other 16 countries that imported embryos but did not submit any data to this committee. These data suggest that embryo technologies are currently in use in 28.7% of the countries worldwide. The data of the embryo industry in 2021 on the four most representative farm animal species are summarized in Table 2 (total of embryos, produced or collected) and Table 3 (numbers of transferred embryos). Altogether, the numbers depict a very positive moment for the industry, with more than 2 million embryos collected or produced in these species alone. The most remarkable increase occurred in cattle. Over 1.5 million in vitro-produced (IVP) embryos were recorded, an increase of 31.5% compared with 2020 (1,521,018 vs. 1,156,422, respectively). Interestingly and divergent from the tendency observed since 2015, the number of in vivo-derived (IVD) embryos collected and transferred in 2021 has also increased compared with 2020 (+ 6.8% and+ 6.5%, respectively); yet in lesser proportions than those observed for IVP embryos. The simultaneous grow in the numbers of IVP and IVD embryos recorded led to an overall increase of 25.6% in the world total cattle embryos, the greatest since 2003. This was a general trend, with all top 10 countries in bovine embryo production in 2020 reporting increased numbers in 2021. Worldwide, IVP embryos accounted for, in 2021, 79.7% of all transferrable cattle embryos. We observed a similar trend in sheep, with both numbers of IVD and IVP embryos increasing in 2021 compared with 2020 (+ 38.1% and+ 344.0%, respectively). On the other hand, the increase in the number of horse embryos recorded in 2021 (+ 9.6%) was mainly driven by an increase in IVP activity (+ 34.5%), whereas the number of IVD embryos remained similar to 2020 (25,475 vs. 25,219, respectively;+ 1.0%). In goats, the increase in the number of IVP embryos (+ 179.3%) was partially compensated by a decrease in the