Development of Tropical Spastic Paraparesis in Human T-Lymphotropic Virus Type 1 Carriers Is Influenced by Interleukin 28B Gene Polymorphisms

A Treviño, M Lopez, E Vispo, A Aguilera… - Clinical Infectious …, 2012 - academic.oup.com
Interleukin 28B (IL28B) rs12979860 polymorphisms were examined in 41 individuals with
human T-lymphotrophic virus type 1 (HTLV-1). The alleles CT/TT were more frequent in 12 …

IL28B gene polymorphism SNP rs8099917 genotype GG is associated with HTLV-1-associated myelopathy/tropical spastic paraparesis (HAM/TSP) in HTLV-1 carriers

T Assone, FV Souza, KO Gaester… - PLoS neglected …, 2014 - journals.plos.org
… The aim of this research was to evaluate whether IL28B gene … by genetic ancestry. Given
the historical context of the Brazilian colonization, the population displays unique genetic

HTLV‐1‐Associated Myelopathy/Tropical Spastic Paraparesis Is Not Associated with SNP rs12979860 of the IL‐28B Gene

ACR Vallinoto, BB Santana, KSG Sá… - Mediators of …, 2015 - Wiley Online Library
… the rs12979860 polymorphism in the IL-28B gene and HTLV-1 infection as well as the
development of HTLV-1-associated myelopathy/tropical spastic paraparesis (HAM/TSP). HTLV-1-…

Interferon lambda family along with HTLV-1 proviral load, tax, and HBZ implicated in the pathogenesis of myelopathy/tropical spastic paraparesis

SH Mozhgani, HR Jahantigh, H Rafatpanah… - Neurodegenerative …, 2018 - karger.com
HTLV-1-associated myelopathy/tropical spastic paraparesis (HAM/TSP) is a chronic
neuroinflammatory disease related to human T lymphotropic virus type 1 (HTLV-1) infection. …

Lack of evidence to support the association of a single IL28B genotype SNP rs12979860 with the HTLV-1 clinical outcomes and proviral load

SS Sanabani, Y Nukui, J Pereira, AC da Costa… - BMC infectious …, 2012 - Springer
spastic paraparesis patients and Adult T Cell Leukemia/Lymphoma. (B) Interleukin 28B CC
… do not support the IL28B gene polymorphism as a novel genetic susceptibility marker, either …

Spastic paraplegia related loss of Kinesin-1 function causes developmental defects and synapse degeneration in a Drosophila model

CD Schneider - 2016 - tobias-lib.ub.uni-tuebingen.de
… in the gene coding for the neuronal Kinesin-1 isoform KIF5A cause spastic paraplegia type
… The mechanism behind Kinesin-1 mutation leading to slow progressing spasticity and …

[PDF][PDF] Complex Genetics and Disease Mechanisms in

G Şimşir - ndal.ku.edu.tr
… Mutations in 18 different genes were identified as the genetic cause in 26 families, which …
in hereditary spastic paraplegias and other neurodegenerative disease genes showed that …

Kinematic gait deficits at the trunk and pelvis: characteristic features in children with hereditary spastic paraplegia

B Adair, J Rodda, JL McGinley… - … Medicine & Child …, 2016 - Wiley Online Library
… Hereditary spastic paraplegia (HSP) is an umbrella term for a group of … those with genetic
confirmation, HSP was diagnosed clinically on the basis of progressive childhood spasticity, …

The Relevance of HTLV-1-associated Myelopathy/Tropical Spastic Paraparesis in Iran: A Review Study.

M Keikha, MKZ Babaki… - Reviews in Clinical …, 2019 - search.ebscohost.com
… pol gene encodes two main enzymes (reverse transcriptase [RT] and integrase), the pro gene
encodes protease, and the env gene … The pX region also contains regulatory genes, which …

Factors related to fatalities and clinical progression of Crimean-Congo hemorrhagic fever patients and the effects of IL 28-B gene polymorphism

FY Aytekin, HŞ Barut, A Rüstemoğlu, A Atay, Ö Günal… - Archives of …, 2019 - Springer
… serious prognosis and IL 28-B gene polymorphism were investigated… The IL 28-B rs12979860
polymorphism was identified by … In addition to the IL 28-B analysis results, a variety of data …