Retinal prosthesis (RP) electrically stimulates the retinal cells of the blind to restore visual loss, and it is essential to increase the number of channels for higher spatial-resolution information [1]. Conventional RP SoC with an external camera and an image processor has a limitation of increasing the number of channels due to bandwidth bottleneck, and power consumption from high supply voltage [2]. The photo-diode based RP SoC [3] can reduce the data rate by using incident light directly. However, conductive human retinal environment blurs the electrical stimulus pattern based on the light-intensity difference; thus it is challenging to meet the minimum spatial-resolution information (>1000 Ch) to recognize faces [1], [4]. This clinical result raises the necessity for integration of an image processor within the photo-diode based RP SoC. Also, cell damage due to temperature increase must be regulated (no more than 1°C increase allowed). To date, no work in the literature addresses the localized temperature regulation. In order to address these issues, we propose a 1225-channel Neuromorphic Retinal Prosthesis (NRP) SoC integrated with 56.3nW/Ch Neuromorphic Image Processor and the localized (49-point) temperature regulation circuit.