Engineering hierarchical vasculatures is critical for creating implantable functional thick
tissues. Current approaches focus on fabricating mesoscale vessels for implantation or
hierarchical microvascular in vitro models, but a combined approach is yet to be achieved to
create engineered tissue flaps. Here, millimetric vessel‐like scaffolds and 3D bioprinted
vascularized tissues interconnect, creating fully engineered hierarchical vascular constructs
for implantation. Endothelial and support cells spontaneously form microvascular networks …

Millimetric tubular scaffolds and 3D bioprinted vascularized collagen hydrogels are
combined by Shulamit Levenberg and co-workers in article number 2102661 to create
engineered hierarchically vascularized tissues (engineered flap) consisting of rich
microvascular networks in communication with an engineered endothelium. The in vitro
cultured flaps are directly anastomosed to the host vasculature, successfully perfusing the
implanted tissue. This work represents a step forward to achieving large fully engineered …