A" Dual-Addition" Calcium Fluorescence Assay for the High-Throughput Screening of Recombinant G Protein-Coupled Receptors.
C Xiong, D Baker, P Pietrantonio - Journal of Visualized …, 2022 - europepmc.org
G protein-coupled receptors (GPCRs) represent the largest superfamily of receptors and are
the targets of numerous human drugs. High-throughput screening (HTS) of random small
molecule libraries against GPCRs is used by the pharmaceutical industry for target-specific
drug discovery. In this study, an HTS was employed to identify novel small-molecule ligands
of invertebrate-specific neuropeptide GPCRs as probes for physiological studies of vectors
of deadly human and veterinary pathogens. The invertebrate-specific kinin receptor was …
the targets of numerous human drugs. High-throughput screening (HTS) of random small
molecule libraries against GPCRs is used by the pharmaceutical industry for target-specific
drug discovery. In this study, an HTS was employed to identify novel small-molecule ligands
of invertebrate-specific neuropeptide GPCRs as probes for physiological studies of vectors
of deadly human and veterinary pathogens. The invertebrate-specific kinin receptor was …
A" Dual-Addition" Calcium Fluorescence Assay for the High-Throughput Screening of Recombinant G Protein-Coupled Receptors
C Xiong, D Baker, P Pietrantonio - jove.com
G protein-coupled receptors (GPCRs) represent the largest superfamily of receptors and are
the targets of numerous human drugs. High-throughput screening (HTS) of random small
molecule libraries against GPCRs is used by the pharmaceutical industry for target-specific
drug discovery. In this study, an HTS was employed to identify novel small-molecule ligands
of invertebrate-specific neuropeptide GPCRs as probes for physiological studies of vectors
of deadly human and veterinary pathogens. The invertebrate-specific kinin receptor was …
the targets of numerous human drugs. High-throughput screening (HTS) of random small
molecule libraries against GPCRs is used by the pharmaceutical industry for target-specific
drug discovery. In this study, an HTS was employed to identify novel small-molecule ligands
of invertebrate-specific neuropeptide GPCRs as probes for physiological studies of vectors
of deadly human and veterinary pathogens. The invertebrate-specific kinin receptor was …
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