A bioorthogonal 'turn-on'fluorescent probe for tracking mitochondrial nitroxyl formation
Chemical Communications, 2017•pubs.rsc.org
A bioreductant-resistant 'turn-on'chemodosimetric fluorescent probe Mito-1 has been
developed for the detection of mitochondrial HNO in live cells. Mito-1 enables the detection
of HNO as low as∼ 18 nM. It has the capability to detect both exogenous and endogenous
mitochondrial HNO formations in cellular milieus by providing fluorescence images. Its two-
photon imaging ability fosters its use as a noninvasive imaging tool for the detection of
mitochondrial nitroxyl.
developed for the detection of mitochondrial HNO in live cells. Mito-1 enables the detection
of HNO as low as∼ 18 nM. It has the capability to detect both exogenous and endogenous
mitochondrial HNO formations in cellular milieus by providing fluorescence images. Its two-
photon imaging ability fosters its use as a noninvasive imaging tool for the detection of
mitochondrial nitroxyl.
A bioreductant-resistant ‘turn-on’ chemodosimetric fluorescent probe Mito-1 has been developed for the detection of mitochondrial HNO in live cells. Mito-1 enables the detection of HNO as low as ∼18 nM. It has the capability to detect both exogenous and endogenous mitochondrial HNO formations in cellular milieus by providing fluorescence images. Its two-photon imaging ability fosters its use as a noninvasive imaging tool for the detection of mitochondrial nitroxyl.
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