[HTML][HTML] A circular RNA binds to and activates AKT phosphorylation and nuclear localization reducing apoptosis and enhancing cardiac repair
Y Zeng, WW Du, Y Wu, Z Yang, FM Awan, X Li… - Theranostics, 2017 - ncbi.nlm.nih.gov
As central nodes in cardiomyocyte signaling, nuclear AKT appears to play a cardio-
protective role in cardiovascular disease. Here we describe a circular RNA, circ-Amotl1 that
is highly expressed in neonatal human cardiac tissue, and potentiates AKT-enhanced
cardiomyocyte survival. We hypothesize that circ-Amotl1 binds to PDK1 and AKT1, leading
to AKT1 phosphorylation and nuclear translocation. In primary cardiomyocytes, epithelial
cells, and endothelial cells, we found that forced circ-Amotl1 expression increased the …
protective role in cardiovascular disease. Here we describe a circular RNA, circ-Amotl1 that
is highly expressed in neonatal human cardiac tissue, and potentiates AKT-enhanced
cardiomyocyte survival. We hypothesize that circ-Amotl1 binds to PDK1 and AKT1, leading
to AKT1 phosphorylation and nuclear translocation. In primary cardiomyocytes, epithelial
cells, and endothelial cells, we found that forced circ-Amotl1 expression increased the …
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