A class I (Senofilcon A) soft contact lens prevents UVB-induced ocular effects, including cataract, in the rabbit in vivo
FJ Giblin, LR Lin, VR Leverenz… - … ophthalmology & visual …, 2011 - iovs.arvojournals.org
FJ Giblin, LR Lin, VR Leverenz, L Dang
Investigative ophthalmology & visual science, 2011•iovs.arvojournals.orgPurpose.: UVB radiation from sunlight is known to be a risk factor for human cataract. The
purpose in this study was to investigate the ability of a class I UV-blocking soft contact lens to
protect against UVB-induced effects on the ocular tissues of the rabbit in vivo. Methods.:
Eyes of rabbits were exposed to UVB light for 30 minutes (270–360 nm, peak at 310 nm, 1.7
mW/cm 2 on the cornea). Eyes were irradiated in the presence of either a UV-blocking
senofilcon A contact lens, a minimally UV-blocking lotrafilcon A contact lens, or no contact …
purpose in this study was to investigate the ability of a class I UV-blocking soft contact lens to
protect against UVB-induced effects on the ocular tissues of the rabbit in vivo. Methods.:
Eyes of rabbits were exposed to UVB light for 30 minutes (270–360 nm, peak at 310 nm, 1.7
mW/cm 2 on the cornea). Eyes were irradiated in the presence of either a UV-blocking
senofilcon A contact lens, a minimally UV-blocking lotrafilcon A contact lens, or no contact …
Abstract
Purpose.: UVB radiation from sunlight is known to be a risk factor for human cataract. The purpose in this study was to investigate the ability of a class I UV-blocking soft contact lens to protect against UVB-induced effects on the ocular tissues of the rabbit in vivo.
Methods.: Eyes of rabbits were exposed to UVB light for 30 minutes (270–360 nm, peak at 310 nm, 1.7 mW/cm 2 on the cornea). Eyes were irradiated in the presence of either a UV-blocking senofilcon A contact lens, a minimally UV-blocking lotrafilcon A contact lens, or no contact lens at all. Effects on the cornea and lens were evaluated at various times after exposure.
Results.: Eyes irradiated with no contact lens protection showed corneal epithelial cell loss plus lens epithelial cell swelling, vacuole formation, and DNA single-strand breaks, as well as lens anterior subcapsular opacification. The senofilcon A lens protected nearly completely against the UVB-induced effects, whereas the lotrafilcon A lens showed no protection.
Conclusions.: The results indicate that use of a senofilcon A contact lens is beneficial in protecting ocular tissues of the rabbit against the harmful effects of UVB light, including photokeratitis and cataract.
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