A Common Polymorphism in the CYP3A7 Gene Is Associated with a Nearly 50% Reduction in Serum Dehydroepiandrosterone Sulfate Levels
P Smit, RHN van Schaik, M van der Werf… - The Journal of …, 2005 - academic.oup.com
Abstract Context: CYP3A7, expressed in the human fetal liver and normally silenced after
birth, plays a major role in the 16α-hydroxylation of dehydroepiandrosterone (DHEA), DHEA
sulfate (DHEAS), and estrone. Due to a replacement of part of the CYP3A7 promoter with a
sequence identical with the same region in the CYP3A4 promoter (referred to as CYP3A7*
1C), some individuals still express a variant of the CYP3A7 gene later in life. Objective: The
objective of this study was to examine the effect of the CYP3A7* 1C polymorphism on serum …
birth, plays a major role in the 16α-hydroxylation of dehydroepiandrosterone (DHEA), DHEA
sulfate (DHEAS), and estrone. Due to a replacement of part of the CYP3A7 promoter with a
sequence identical with the same region in the CYP3A4 promoter (referred to as CYP3A7*
1C), some individuals still express a variant of the CYP3A7 gene later in life. Objective: The
objective of this study was to examine the effect of the CYP3A7* 1C polymorphism on serum …
[PDF][PDF] A Common Polymorphism in the CYP3A7 Gene is Associated With a Nearly 50% Reduction in Serum DHEAS levels
P Smit, RHN van Schaik, M van der Werf - … Glucocorticoid Sensitivity in …, 2006 - repub.eur.nl
Abstract Context: CYP3A7, expressed in the human fetal liver and normally silenced after
birth, plays a major role in the 16α-hydroxylation of dehydroepiandrosterone (DHEA),
DHEAS, and estrone. Due to a replacement of part of the CYP3A7 promoter with a sequence
identical to the same region in the CYP3A4 promoter (referred to as CYP3A7* 1C), some
individuals still express a variant of the CYP3A7 gene later in life. Objective: The objective of
this study was to examine the effect of the CYP3A7* 1C polymorphism on serum steroid …
birth, plays a major role in the 16α-hydroxylation of dehydroepiandrosterone (DHEA),
DHEAS, and estrone. Due to a replacement of part of the CYP3A7 promoter with a sequence
identical to the same region in the CYP3A4 promoter (referred to as CYP3A7* 1C), some
individuals still express a variant of the CYP3A7 gene later in life. Objective: The objective of
this study was to examine the effect of the CYP3A7* 1C polymorphism on serum steroid …
以上显示的是最相近的搜索结果。 查看全部搜索结果