In this study, extract from Manihot esculenta was evaluated as an ecofriendly coagulant for treating turbid wastewater. Chemical and morphological characterization of the coagulant was performed using field emission scanning electron microscopy (FESEM) with energy dispersive spectroscopy (EDS) and Fourier transform infrared (FTIR) spectroscopy. The coagulation jar tests were done on the basis of a central composite rotatable design (CCRD), while parametric modeling and optimization of the process was done via the statistically inclined response surface methodology (RSM) and the neural intelligence tool (artificial neural networks (ANN). From the FTIR spectra, the coagulant was shown to be characterized by diverse functional groups that have been reported to have a synergistic effect on coagulation. The morphological characteristics obtained from FESEM showed a porous structure. The compositional analysis obtained with EDS showed that the major constituents were carbon and oxygen, which accounted for 67.8% and 23.9%, respectively. Other elements present in the coagulants were potassium (4.6 %), bromine (1.2 %), calcium (1.2 %), phosphorus (0.7 %), magnesium (0.4 %) and silicon (0.3 %). RSM and ANN showed adequacy in modeling the process, although ANN clearly outperformed RSM with better goodness of fit statistical indicators. RSM and ANN both predicted similar maximum turbidity removal (95.4 % and 96.7 %, respectively) under optimized conditions. Thus, Manihot esculenta leaf extract could serve as an efficient coagulant for the remediation of turbid wastewater.