A comprehensive summary of LL-37, the factotum human cathelicidin peptide
Cathelicidins are a group of antimicrobial peptides. Since their discovery, it has become
clear that they are an exceptional class of peptides, with some members having pleiotropic
effects. Not only do they possess an antibacterial, antifungal and antiviral function, they also
show a chemotactic and immunostimulatory/-modulatory effect. Moreover, they are capable
of inducing wound healing, angiogenesis and modulating apoptosis. Recent insights even
indicate for a role of these peptides in cancer. This review provides a comprehensive …
clear that they are an exceptional class of peptides, with some members having pleiotropic
effects. Not only do they possess an antibacterial, antifungal and antiviral function, they also
show a chemotactic and immunostimulatory/-modulatory effect. Moreover, they are capable
of inducing wound healing, angiogenesis and modulating apoptosis. Recent insights even
indicate for a role of these peptides in cancer. This review provides a comprehensive …