Calponin 2 (h2 calponin, CNN2) is an actin-binding protein implicated in cytoskeletal
organization. We have found that the expression of calponin 2 is relatively restricted to
vasculature from 16 to 30 h post-fertilization during zebrafish (Danio rerio) development.
Forty-eight hours after injecting antisense morpholino oligos against calponin 2 into
embryos at the 1-4-cell stage, zebrafish demonstrated various cardiovascular defects,
including sluggish axial and head circulation, absence of circulation in intersegmental …