A distinct plasma lipid signature associated with poor prognosis in castrationresistant prostate cancer

HM Lin, KL Mahon, JM Weir, PA Mundra… - … Journal of Cancer, 2017 - Wiley Online Library
… validated a novel three-lipid signature associated with poor prognosis in CRPC. Further
research … modulation of lipid levels associated with poor prognosis can improve patient outcome. …

Circulating Lipid Profiles Associated With Resistance to Androgen Deprivation Therapy in Localized Prostate Cancer

HM Lin, X Yang, MM Centenera, K Huynh… - JCO Precision …, 2024 - ascopubs.org
… circulating lipid profiles are associated with ADT/ARPI resistance in … Our two different
experimental approaches of studying ADT/… Prognostic Markers (plasma lipid prognostic signature

Relationship between circulating lipids and cytokines in metastatic castration-resistant prostate cancer

HM Lin, N Yeung, JF Hastings, DR Croucher, K Huynh… - Cancers, 2021 - mdpi.com
… , a poor prognostic three-lipid signature (3LS) in the plasma of … prognosis in both castration
(mCRPC) and non-castration … with similar lipid profiles tend to have different cytokine profiles, …

Combined impact of lipidomic and genetic aberrations on clinical outcomes in metastatic castration-resistant prostate cancer

B Mak, HM Lin, EM Kwan, H Fettke, B Tran, ID Davis… - BMC medicine, 2022 - Springer
survival (rPFS) in mCRPC [14,15,16,17]. We have derived and validated a poor prognostic
3-lipid signature (… relationship between the poor prognostic 3-lipid signature, somatic genetic …

Modulation of plasma lipidomic profiles in metastatic castration-resistant prostate cancer by simvastatin

B Mak, HM Lin, T Duong, KL Mahon, AM Joshua… - Cancers, 2022 - mdpi.com
treatment for mCRPC can modify a poor prognostic circulating lipidomic profile represented
by a validated 3-lipid signature (… received with simvastatin were also not significantly different

Untargeted lipidomics reveal association of elevated plasma C18 ceramide levels with reduced survival in metastatic castration-resistant prostate cancer patients

C Cattrini, M Manfredi, P Barboro, M Ghirimoldi… - Scientific Reports, 2023 - nature.com
prognostic 3-lipid signaturesignature was associated with poor outcome at different disease
stages, and elevated circulating sphingolipids, especially ceramides (Cer), were associated

Novel gene signatures predictive of patient recurrence-free survival and castration resistance in prostate cancer

B Zhang, Z Zhang, H Hu, JT Dong - Cancers, 2021 - mdpi.com
signatures is limited. This study aims to identify castration-resistant PCa (CRPC)-associated
Another unique aspect of this study is that both CRPC and HSPC samples used for DEGs …

Lipid metabolism and endocrine resistance in prostate cancer, and new opportunities for therapy

GE Stoykova, IR Schlaepfer - International journal of molecular sciences, 2019 - mdpi.com
… to castrate resistant PCa, … associated with metabolic and lipid-specific changes in PCa
patients. The role and relative contribution of lipid and glucose metabolism in PCa is different from …

Lipidomic profiling in patients with metastatic castration-resistant prostate cancer (mCRPC)

C Cattrini - 2023 - tesidottorato.depositolegale.it
… might be related to the different exposure to treatment, which is … (CNV) in plasma DNA are
associated with worse outcome in … prognostic effect of the previously reported 3-lipid signature

[PDF][PDF] A distinct plasma lipid signature associated with poor prognosis in castration-resistant prostate cancer 2

G Gurney, G Marx, MR Stockler, P Consortium12… - 2017 - minerva-access.unimelb.edu.au
… and validated a novel three-lipid signature associated with 303 poor prognosis in CRPC.
Further … 304 of lipid levels associated with poor prognosis can improve patient outcome. 305 …