A genomic regulatory element that directs assembly and function of immune-specific AP-1–IRF complexes
E Glasmacher, S Agrawal, AB Chang, TL Murphy… - Science, 2012 - science.org
Interferon regulatory factor 4 (IRF4) and IRF8 regulate B, T, macrophage, and dendritic cell
differentiation. They are recruited to cis-regulatory Ets-IRF composite elements by PU. 1 or
Spi-B. How these IRFs target genes in most T cells is enigmatic given the absence of
specific Ets partners. Chromatin immunoprecipitation sequencing in T helper 17 (TH17) cells
reveals that IRF4 targets sequences enriched for activating protein 1 (AP-1)–IRF composite
elements (AICEs) that are co-bound by BATF, an AP-1 factor required for TH17, B, and …
differentiation. They are recruited to cis-regulatory Ets-IRF composite elements by PU. 1 or
Spi-B. How these IRFs target genes in most T cells is enigmatic given the absence of
specific Ets partners. Chromatin immunoprecipitation sequencing in T helper 17 (TH17) cells
reveals that IRF4 targets sequences enriched for activating protein 1 (AP-1)–IRF composite
elements (AICEs) that are co-bound by BATF, an AP-1 factor required for TH17, B, and …
A genomic regulatory element that directs assembly and function of immune-specific AP-1-IRF complexes (P1322)
E Glasmacher, S Agrawal, A Chang… - The Journal of …, 2013 - journals.aai.org
Abstract Interferon regulatory factor 4 (IRF4) and IRF8 regulate B, T, macrophage, and
dendritic cell differentiation. They are recruited to cis-regulatory Ets-IRF composite elements
by PU. 1 or Spi-B. How these IRFs target genes in most T cells is enigmatic given the
absence of specific Ets partners. Chromatin immunoprecipitation sequencing in T helper 17
(T (H) 17) cells reveals that IRF4 targets sequences enriched for activating protein 1 (AP-1)-
IRF composite elements (AICEs) that are co-bound by BATF, an AP-1 factor required for T …
dendritic cell differentiation. They are recruited to cis-regulatory Ets-IRF composite elements
by PU. 1 or Spi-B. How these IRFs target genes in most T cells is enigmatic given the
absence of specific Ets partners. Chromatin immunoprecipitation sequencing in T helper 17
(T (H) 17) cells reveals that IRF4 targets sequences enriched for activating protein 1 (AP-1)-
IRF composite elements (AICEs) that are co-bound by BATF, an AP-1 factor required for T …
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