… To outweigh its conflicting effects on host defense and pathologic inflammation, we hypothesized
that a ligand-specific blockade would be superior to an unspecific inhibition of Mac-1 in …

… antibody (mAb) blockade 16 or absence 17 of Mac-1 modulates the biological response to
… promotes vascular inflammation. Our goal was to identify genes regulated by Mac-1 and to …

… These observations provide a molecular target for disrupting … result in the infiltration of
inflammatory cells into the blood … The rolling and firm adhesive events scored were ligand specific …

… adhesion steps lead to their retention in the inflamed regions. This part of the recruitment …
adhesion, as did the blockade of Mac-1. The combination of the blockade of Mac-1 as well as α …

… antithrombin III, the described blockade of factor X binding to Mac-1 may participate in the
… -dependent leukocyte adhesion on endothelial cells and thus to attenuate inflammatory and …

… Counter-ligand-specific binding forces of LFA-1 and Mac-1 imply diverse roles … integrins
appear to be attractive therapeutic targets. However, prolonged global blockade of β 2 integrins …

… interacts with the integrin Mac-1, which results in Mac-1–dependent … (3) A blocking anti–Mac-1
antibody inhibited binding of … implications for future treatment strategies that target CD40L. …

… for PMN migration, we observed a larger infiltration of β2 integrin- [117] and MAC-1-[118]…
A ligand-specific blockade of the integrin Mac-1 selectively targets pathologic inflammation …

… Blocking the Mac-1:GP1bα interaction prevents neutrophil extracellular trap formation, 11
and an antibody targeting Mac-1 was shown to block inflammation. Inhibiting the …

… integrins were blocked by controlled release of a blocking … as therapeutic targets to mitigate
macrophage inflammatory … indicate a role for Mac-1 in ligand-specific kinetics of receptor-…