Rationale: This is the first multicenter randomized controlled trial to evaluate the
effectiveness and safety of Zephyr Endobronchial Valve (EBV) in patients with little to no
collateral ventilation out to 12 months. Objectives: To evaluate the effectiveness and safety
of Zephyr EBV in heterogeneous emphysema with little to no collateral ventilation in the
treated lobe. Methods: Subjects were enrolled with a 2: 1 randomization (EBV/standard of
care [SoC]) at 24 sites. Primary outcome at 12 months was the ΔEBV–SoC of subjects with a …

Rationale: Single-center randomized controlled trials of the Zephyr endobronchial valve
(EBV) treatment have demonstrated benefit in severe heterogeneous emphysema. This is
the first multicenter study evaluating this treatment approach. Objectives: To evaluate the
efficacy and safety of Zephyr EBVs in patients with heterogeneous emphysema and
absence of collateral ventilation. Methods: This was a prospective, multicenter 2: 1
randomized controlled trial of EBVs plus standard of care or standard of care alone (SoC) …