A new approach to synthesis of dihalogenated 8-quinolinol derivatives
A Das, S Mukherji - The Journal of Organic Chemistry, 1957 - ACS Publications
A Das, S Mukherji
The Journal of Organic Chemistry, 1957•ACS PublicationsOf the halogenated 8-quinolinols, 5-chloro-7-iodo (Illa) and 5, 7-diiodo-8-quinolinols (Via),
commonly known as Vioform and Diodoquin re-spectively, have proved very useful in
thetreat-ment of intestinal amoebiasis. Among the recently prepared amoebicidal
compounds containing the quinoline group, 5-chloro-7-diethylaminomethyl-8-quinolinol
showed considerable promise in labo-ratory animals according to the preliminary re-sults
reported by Burckhalter and Edgerton. 1 2 Various methods of preparing Ilia from 5-chloro-8 …
commonly known as Vioform and Diodoquin re-spectively, have proved very useful in
thetreat-ment of intestinal amoebiasis. Among the recently prepared amoebicidal
compounds containing the quinoline group, 5-chloro-7-diethylaminomethyl-8-quinolinol
showed considerable promise in labo-ratory animals according to the preliminary re-sults
reported by Burckhalter and Edgerton. 1 2 Various methods of preparing Ilia from 5-chloro-8 …
Of the halogenated 8-quinolinols, 5-chloro-7-iodo (Illa) and 5, 7-diiodo-8-quinolinols (Via), commonly known as Vioform and Diodoquin re-spectively, have proved very useful in thetreat-ment of intestinal amoebiasis. Among the recently prepared amoebicidal compounds containing the quinoline group, 5-chloro-7-diethylaminomethyl-8-quinolinol showed considerable promise in labo-ratory animals according to the preliminary re-sults reported by Burckhalter and Edgerton. 1 2
Various methods of preparing Ilia from 5-chloro-8-quinolinol have been reported. 3-6 Certain patents6· 7 claim its preparation from 8-quinolinol (la) and iodine trichloride; however, the product isolated by Lasker and Ghosh8 by a similar reaction was Via. The authors prepared Ilia and Via9 most conveniently by the treatment of la in hydrochloric
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