A new continuous hybride generator is described. Its characteristics are compared with a conventional hybride generator for the determination of arsenic, antimony and tin by using flame atomic absorption spectrometry. This simple hybride generator combines hybride production and gas-liquid separation in one unit, obviating the use of a separate mixing/reaction coil and gas-liquid separator. Radioactive tracer studies show that a hybride generation efficiency of over 95% is achieved with the new hybride generator and that approximately 90% of monomethylarsonic acid (MMA) is converted to its hybride (methylarsine) within the first 10 s of the hybride generation reaction. Compared to a conventional hybride generator, an improved signal-to-noise ratio is achieved and comparable or less interference from transition metal ions is observed. Cysteine (1% in the sample solution) is effective in reducing interferences during the hybride generation processes. In the presence of cysteine, 10–1000 fold higher amounts of Ni²⁺, Co²⁺ and Cu²⁺ are tolerated in the determination of arsenic, antimony and tin. Cysteine also enhances the signals of arsenic, antimony and tin by 60, 200 and 40%, respectively. Reaction conditions were optimized by using both the simplex optimization method and one-factor-at-a-time method and results are in good agreement.