A new enantioselective synthesis of the anticonvulsant drug pregabalin (lyrica) based on a hydrolytic kinetic resolution method
M Mujahid, M Muthukrishnan - Chirality, 2013 - Wiley Online Library
Chirality, 2013•Wiley Online Library
ABSTRACT A practical and efficient enantioselective synthesis of the anticonvulsant drug
pregabalin is described for the first time using Jacobsen's hydrolytic kinetic resolution of a
terminal epoxide as a key step and a source of chirality. Chirality 25: 965–969, 2013.© 2013
Wiley Periodicals, Inc.
pregabalin is described for the first time using Jacobsen's hydrolytic kinetic resolution of a
terminal epoxide as a key step and a source of chirality. Chirality 25: 965–969, 2013.© 2013
Wiley Periodicals, Inc.
Abstract
A practical and efficient enantioselective synthesis of the anticonvulsant drug pregabalin is described for the first time using Jacobsen's hydrolytic kinetic resolution of a terminal epoxide as a key step and a source of chirality. Chirality 25:965–969, 2013. © 2013 Wiley Periodicals, Inc.
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