CiNii 博士論文 - A novel heart failure mice model of hypertensive heart disease by
angiotensin Ⅱ infusion, nephrectomy, and salt loading … A novel heart failure mice model
of hypertensive heart disease by angiotensin Ⅱ infusion, nephrectomy, and salt loading
アンジオテンシンⅡ負荷,片側腎臓摘出,食塩負荷による新規心不全発症・高血圧性心疾患マウス
モデル … A novel heart failure mice model of hypertensive heart disease by angiotensin Ⅱ
infusion, nephrectomy, and salt loading …

Although the mouse heart failure (HF) model of hypertensive heart disease (HHD) is useful
to investigate the pathophysiology and new therapeutic targets for HHD, the model using
simple experimental procedures and stable phenotypes has not been established. This
study aimed to develop a novel mouse HF model of HHD by combining salt loading and
uninephrectomy with ANG II infusion. Eight-week-old C57BL/6 male mice were treated with
ANG II infusion (AT), ANG II infusion and uninephrectomy (AN), ANG II infusion and salt …