Aging is associated with structural alterations in many regions of the brain. Monitoring these
changes contributes to increasing our understanding of the brain's morphological alterations
across its lifespan, and could allow the identification of departures from canonical
trajectories. Here, we introduce a novel and unique patch-based grading procedure for
estimating a synthetic estimate of cortical aging in cognitively intact individuals. The cortical
age metric is computed based on image similarity between an unknown (test) cortical label …

Résumé Aging is associated with structural alterations in many regions of the brain.
Monitoring these changes contributes to increasing our understanding of the brain's
morphological alterations across its lifespan, and could allow the identification of departures
from canonical trajectories. Here, we introduce a novel and unique patch-based grading
procedure for estimating a synthetic estimate of cortical aging in cognitively intact
individuals. The cortical age metric is computed based on image similarity between an …