… Phase I/II study used a previously untested delivery system for anticancer agents and
demonstrated that direct injection of ONYX-015 … Alterations in the injection methodology, as noted …

… injection of direct intratumoral agents under ultrasound or … that EUS guided transgastric
injection of ONYX-015 adenovirus into … These are mostly phase I/II clinical studies using different …

… A phase I trial of injection of ONYX-015 into locally advanced … However, repeated intratumoral
injection of ONYX-015 under CT … Subsequently, a phase I/II trial was performed under EUS …

… locally advanced pancreatic carcinoma: A phase I/II trial. Oncotarget 2018; 9: 2838–47. …
A phase I/II trial of intratumoral endoscopic ultrasound injection of ONYX-015 with intravenous …

… Generally, phase I/II experimental therapies are reserved for … tested the viral vector via
stereotactic intratumoral administration [ … By injecting this oncolytic adenovirus directly into human …

… intratumoral injections of TNFerade (4 × 10 9 , 4 × 10 10 , and 4 × 10 11 particle units in 2
mL). This was combined with iv … None showed tumor regression with the ONYX-015 injection …

… In conclusion, intratumoral administration of ONYX-015 in combination … endoscopic
ultrasound), 12 metastatic colorectal cancer (administration via the hepatic artery) 13 or intravenously…

… phase I/II trial of intratumoral endoscopic ultrasound injection of ONYX-015 with intravenous
… examined the safety and efficacy of ONYX-015 delivered by EUS FNI with intravenous …

… replication of the oncolytic adenovirus mutant ONYX-015. Future Oncol 2005;1:763-66. 27.
… phase I/II trial of intratumoral endoscopic ultrasound injection of ONYX-015 with intravenous …

… Efficacy has also been documented following intravenous administration in these nude …
novel approaches to intratumoral injection of pancreatic tumors. Endoscopic ultrasound, for …