[HTML][HTML] A post-transcriptional program coordinated by CSDE1 prevents intrinsic neural differentiation of human embryonic stem cells
HJ Lee, D Bartsch, C Xiao, S Guerrero… - Nature …, 2017 - ncbi.nlm.nih.gov
While the transcriptional network of human embryonic stem cells (hESCs) has been
extensively studied, relatively little is known about how post-transcriptional modulations
determine hESC function. RNA-binding proteins play central roles in RNA regulation,
including translation and turnover. Here we show that the RNA-binding protein CSDE1 (cold
shock domain containing E1) is highly expressed in hESCs to maintain their undifferentiated
state and prevent default neural fate. Notably, loss of CSDE1 accelerates neural …
extensively studied, relatively little is known about how post-transcriptional modulations
determine hESC function. RNA-binding proteins play central roles in RNA regulation,
including translation and turnover. Here we show that the RNA-binding protein CSDE1 (cold
shock domain containing E1) is highly expressed in hESCs to maintain their undifferentiated
state and prevent default neural fate. Notably, loss of CSDE1 accelerates neural …
A post-transcriptional program coordinated by CSDE1 prevents intrinsic neural differentiation of human embryonic stem cells
H Ju Lee, D Bartsch, C Xiao, S Guerrero… - Nature …, 2017 - nature.com
While the transcriptional network of human embryonic stem cells (hESCs) has been
extensively studied, relatively little is known about how post-transcriptional modulations
determine hESC function. RNA-binding proteins play central roles in RNA regulation,
including translation and turnover. Here we show that the RNA-binding protein CSDE1 (cold
shock domain containing E1) is highly expressed in hESCs to maintain their undifferentiated
state and prevent default neural fate. Notably, loss of CSDE1 accelerates neural …
extensively studied, relatively little is known about how post-transcriptional modulations
determine hESC function. RNA-binding proteins play central roles in RNA regulation,
including translation and turnover. Here we show that the RNA-binding protein CSDE1 (cold
shock domain containing E1) is highly expressed in hESCs to maintain their undifferentiated
state and prevent default neural fate. Notably, loss of CSDE1 accelerates neural …
以上显示的是最相近的搜索结果。 查看全部搜索结果