A potent neutralizing nanobody against SARSCoV2 with inhaled delivery potential

J Gai, L Ma, G Li, M Zhu, P Qiao, X Li, H Zhang… - MedComm, 2021 - Wiley Online Library
… The results demonstrated that we have creatively developed the first Nb against SARS-CoV-2
with the inhale delivery potential. The novel way of delivery may offer patients more …

Nanobodies as powerful pulmonary targeted biotherapeutics against SARS-CoV-2, pharmaceutical point of view

A Najmeddin, MB Shapourabadi, M Behdani… - … et Biophysica Acta (BBA …, 2021 - Elsevier
… reviewed the potentials of Nanobodies in Covid-19 treatment. … SARS-CoV-2 neutralization
by Nanobodies prevents viral … , Nanobodies, are particularly suited for delivery by inhalation

… delivery of a broadly neutralizing SARS-CoV-2 RBD-specific nanobody prevents clinical, virological, and pathological disease in a Syrian hamster model of COVID-19

TJ Esparza, Y Chen, NP Martin, H Bielefeldt-Ohmann… - MAbs, 2022 - Taylor & Francis
potent single-domain nanobody, NIH-CoVnb-112, specific for the receptor-binding domain
(RBD) of SARS-CoV-2… support for using nanobodies as potentially inhaled therapeutics, there …

Inhaled nanobodies against COVID-19

G Martinez-Delgado - Nature Reviews Immunology, 2020 - nature.com
… So, delivering cytotoxic molecules via nanotubes ensures that decidual nK cells protect … The
protective potential of SARS- CoV-2 neutralizing antibodies (nAbs) has not been validated in …

Inhalable neutralizing antibodies–promising approach to combating respiratory viral infections

MYT Chow, HW Pan, HC Seow, JKW Lam - Trends in pharmacological …, 2023 - cell.com
… to improve efficacy and delivery of antibody therapies against … of inhalation therapy (including
orally and nasally inhaled) of … us to be better equipped to tackle possible future pandemics. …

[HTML][HTML] Nanobodies to multiple spike variants and inhalation of nanobody-containing aerosols neutralize SARS-CoV-2 in cell culture and hamsters

M Aksu, P Kumar, T Güttler, W Taxer, K Gregor, B Mußil… - Antiviral research, 2024 - Elsevier
… -CoV-2 as broadly as possible, binding to the variant RBDs … that the nanobodies Ma28H02
and Ma28H11 are highly potent … a delivery system to cover these epithelia with nanobody. …

A potent bispecific nanobody protects hACE2 mice against SARS-CoV-2 infection via intranasal administration

X Wu, L Cheng, M Fu, B Huang, L Zhu, S Xu, H Shi… - Cell reports, 2021 - cell.com
Neutralizing nanobodies (Nbs) are a potential therapeutic … Nbs are delivered directly to the
lungs by an inhaler given their … lung RSV titers by the pulmonary administration of inhalation ( …

Respiratory delivery of passive immunotherapies for SARS-CoV-2 prophylaxis and therapy

D Focosi, F Maggi - Human Vaccines & Immunotherapeutics, 2023 - Taylor & Francis
inhalation device and summarize evidence from animal models and early clinical trials
supporting the respiratory delivery (… , potentially hampering their full development: eg, nanobodies

Inhalable Nanobody (PiN-21) prevents and treats SARS-CoV-2 infections in Syrian hamsters at ultra-low doses

S Nambulli, Y Xiang, NL Tilston-Lunel, LJ Rennick… - Science …, 2021 - science.org
… low efficiency of intravenously delivering these relatively large … the in vivo neutralizing
activities of mAbs (34–36), drive potential … Compared to 8 hours after inhalation, we found that the …

A bispecific nanobody dimer broadly neutralizes SARS-CoV-1 & 2 variants of concern and offers substantial protection against Omicron via low-dose intranasal …

H Ma, X Zhang, W Zeng, J Zhou, X Chi, S Chen… - Cell Discovery, 2022 - nature.com
… arsenal against SARS-CoV-1, provides potential therapeutic … Inhalation of conventional
antibodies as well as Nbs has been … To test 2-3-Fc for protection in vivo via in delivery, four dose …