[HTML][HTML] A pre-formulation study of tetracaine loaded in optimized nanostructured lipid carriers
SR Castro, LNM Ribeiro, MC Breitkreitz… - Scientific reports, 2021 - nature.com
Tetracaine (TTC) is a local anesthetic broadly used for topical and spinal blockade, despite
its systemic toxicity. Encapsulation in nanostructured lipid carriers (NLC) may prolong TTC
delivery at the site of injection, reducing such toxicity. This work reports the development of
NLC loading 4% TTC. Structural properties and encapsulation efficiency (% EE> 63%)
guided the selection of three pre-formulations of different lipid composition, through a 23
factorial design of experiments (DOE). DLS and TEM analyses revealed average sizes (193 …
its systemic toxicity. Encapsulation in nanostructured lipid carriers (NLC) may prolong TTC
delivery at the site of injection, reducing such toxicity. This work reports the development of
NLC loading 4% TTC. Structural properties and encapsulation efficiency (% EE> 63%)
guided the selection of three pre-formulations of different lipid composition, through a 23
factorial design of experiments (DOE). DLS and TEM analyses revealed average sizes (193 …
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