Globalization trends in integrated circuit (IC) design using deep submicron (DSM) technologies are leading to increased vulnerability of ICs against malicious intrusions. These malicious intrusions are referred as hardware Trojans. One way to address this threat is to utilize unique electrical signatures of ICs. However, this technique requires analyzing extensive sensor data to detect the intruded integrated circuits. In order to overcome this limitation, we propose to combine the signature extraction mechanism with machine learning algorithms to develop a self-learning framework that can detect the intruded integrated circuits. The proposed approach applies the lazy, eager or probabilistic learners to generate self-learning prediction model based on the electrical signatures. In order to validate this framework, we applied it on a recently proposed signature based hardware Trojan detection technique. The cross validation comparison of these learner shows that eager learners are able to detect the intrusion with 96% accuracy and also require less amount of memory and processing power compared to other machine learning techniques.