[HTML][HTML] A single amino acid substitution on the surface of a natural hevein isoform (Hev b 6.0202), confers different IgE recognition
CA Reyes-López, M Pedraza-Escalona, G Mendoza… - FEBS letters, 2006 - Elsevier
Decreased immune reactivity of isoforms of major allergens has been reported. However,
such claims have always been based on experiments with recombinant proteins. This work
describes the molecular and physicochemical characterization of a hevein (Hev b 6.0201)
natural isoform (Hev b 6.0202), which is present in rubber latex from Hevea brasiliensis. The
isoallergen has a single substitution Asn14Asp, which gives rise to local differences in the
surface potential, as observed from the crystal structure presented here. Besides, ELISA …
such claims have always been based on experiments with recombinant proteins. This work
describes the molecular and physicochemical characterization of a hevein (Hev b 6.0201)
natural isoform (Hev b 6.0202), which is present in rubber latex from Hevea brasiliensis. The
isoallergen has a single substitution Asn14Asp, which gives rise to local differences in the
surface potential, as observed from the crystal structure presented here. Besides, ELISA …
[PDF][PDF] A single amino acid substitution on the surface of a natural hevein isoform (Hev b 6.0202), confers different IgE recognition
CASR LOPEZ - 2006 - rdcb.cbg.ipn.mx
Decreased immune reactivity of isoforms of major allergens has been reported. However,
such claims have always been based on experiments with recombinant proteins. This work
describes the molecular and physicochemical characterization of a hevein (Hev b 6.0201)
natural isoform (Hev b 6.0202), which is present in rubber latex from Hevea brasiliensis. The
isoallergen has a single substitution Asn14Asp, which gives rise to local differences in the
surface potential, as observed from the crystal structure presented here. Besides, ELISA …
such claims have always been based on experiments with recombinant proteins. This work
describes the molecular and physicochemical characterization of a hevein (Hev b 6.0201)
natural isoform (Hev b 6.0202), which is present in rubber latex from Hevea brasiliensis. The
isoallergen has a single substitution Asn14Asp, which gives rise to local differences in the
surface potential, as observed from the crystal structure presented here. Besides, ELISA …
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