Malaria parasites have a complex life cycle featuring diverse developmental strategies, each
uniquely adapted to navigate specific host environments. Here we use single-cell
transcriptomics to illuminate gene usage across the transmission cycle of the most virulent
agent of human malaria-Plasmodium falciparum. We reveal developmental trajectories
associated with the colonization of the mosquito midgut and salivary glands and elucidate
the transcriptional signatures of each transmissible stage. Additionally, we identify both …