The human-and animal-adapted lineages of the Mycobacterium tuberculosis complex
(MTBC) are thought to have expanded from a common progenitor in Africa. However, the
molecular events that accompanied this emergence remain largely unknown. Here, we
describe two MTBC strains isolated from patients with multidrug resistant tuberculosis,
representing an as-yet-unknown lineage, named Lineage 8 (L8), seemingly restricted to the
African Great Lakes region. Using genome-based phylogenetic reconstruction, we show that …

The human-and animal-adapted lineages of the Mycobacterium tuberculosis complex
(MTBC) are thought to have clonally expanded from a common progenitor in Africa.
However, the molecular events that accompanied this emergence remain largely unknown.
Here, we describe two MTBC strains isolated from patients with multidrug-resistant
tuberculosis, representing an as-yet-unknown lineage, named Lineage 8 (L8), seemingly
restricted to the African Great Lakes region. Using genome-based phylogenetic …